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ra0001p287 | (1) | WCRB2014

Short-term administration of ulipristal acetate modulates endometrial sex steroid receptor expression and cell proliferation markers

Murray Alison A , Shaw Grace G , Nicol Moira , Williams Alistair R W , Saunders Philippa T K , Critchley Hilary O D

Introduction: Uterine fibroids cause pain, pressure symptoms and heavy menstrual bleeding (HMB). Fibroid growth is sex steroid dependent. The selective progesterone receptor (PR) modulator (SPRM), ulipristal acetate (UPA) reduces fibroid size and alleviates HMB in 90% of women. UPA has both agonist and antagonist properties and induces (S)PRM-associated endometrial changes (PAEC). The mechanism of UPA action and aetiology of PAEC are unknown. We propose that modulation of ster...

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Short-term administration of ulipristal acetate modulates endometrial sex steroid receptor expression and cell proliferation markers

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